In 1919 De Pisis moved to Rome, where he started to paint he is best known for his cityscapes, metaphysically-inspired maritime scenes, and still lifes, especially those depicting flowers.
He spent his life in Rome, Paris and Venice. He was seen as a very extravagant man. He used to have a pet parrot named Coco, and in Venice he had two personal gondoliers on 24-hour duty, who wore black-and-gold livery.
De Pisis's work was shown twice in the Venice Biennale: once during his life, and once posthumously. He also executed a large body of lesser-known work, comprising homoerotic sketches of the male nude.
De Pisis's work for the Collezione Verzocchi in 1949-1950 is now housed in the Pinacoteca Civica of Forlì. A large portion of his work is also housed in the Museo Filippo de Pisis in Ferrara.
He died in Milan after a long illness, in 1956.