He studied art there at the École Nationale Supérieure des Beaux-Arts (National School of the Fine Arts) and worked in the studio of the painter Eugène Narbonne. Sustained by the picture-dealer Maurice Garnier, Buffet produced religious pieces, landscapes, portraits and still-lives. As a real passionated artist, he created more than 8,000 paintings and many prints as well.
In 1946, he presented his first painting shown, a self-portrait, at the Galerie Beaux-Arts. After that, he had at least one major exhibition every year.
In 1955, he was awarded the first prize by the magazine Connaissance des arts, which named the 10 best post-war artists. Three years after that, when he was 30, the first retrospective of his work was held at the Galerie Charpentier.
In 1973, Bernard Buffet was named "Chevalier de la Légion d'honneur".
During the same year Bernard Buffet Museum was founded by Kiichiro Okano, in Surugadaira, Japan.
When he became old he suffered from Parkinson's disease and was no longer able to work. Buffet committed suicide at his home in Tourtour, southern France, on October 4, 1999.